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peripheral tolerance
Peripheral tolerance is immunological tolerance developed after autoreactive T and B cells mature and enter the periphery. These include the suppression of autoreactive cells by 'regulatory' T cells (Tregs) and the generation of hyporesponsiveness (anergy) in lymphocytes which encounter antigen in the absence of the co-stimulatory signals that accompany inflammation, or in the presence of co-inhibitory signals.
==Ignorance==
Potentially self-reactive T-cells are not activated at immunoprivileged sites, where antigens are expressed in non-surveillanced areas. This can occur in the testes, for instance. Anatomical barriers can separate the lymphocytes from the antigen, an example is the central nervous system (the blood-brain-barrier). Naive T-cells are not present in high numbers in peripheral tissue, but stay mainly in the circulation and lymphoid tissue.
Some antigens are at too low a concentration to cause an immune response - a subthreshold stimulation will lead to apoptosis in a T cell.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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